How does DRP work?

Our drug response platform allows to functionally test the activity and ex vivo efficacy of dozens to hundreds of small molecule inhibitors. By automated fluorescence microscopy we measure the number of malignant cells surviving a given drug treatment relative to a vehicle control. From the resulting dose-response curves we derive pharmacological parameters such as the half-maximal effect concentration (EC₅₀) or the integrated area under the curve (AUC). These patient-specific data points are compared to all previously tested drug profiles thus contextualizing the sensitivity fingerprint within the entire patient cohort. Beyond single-drugs we also measure selected drug combinations and quantify synergistic effects between medicines.